2018 Grantees

The Albert Einstein College of Medicine

  • To be announced

The Jackson Laboratory

  • To be announced

The University of Alabama at Birmingham

  • Karthikeyani Chellappa, University of Pennsylvania: NAD metabolism and Aging: Impact on the composition of the gut microbiome
  • Helen E. Collins, University of Alabama at Birmingham: Dysregulation of local calcium signaling increases risk of diabetic cardiomyopathy in the aging female heart
  • Dang-Fu Dai, University of Iowa: Mitochondrial Oxidative Stress in Kidney Aging and Chronic Kidney Diseases
  • Amit Hagar, Indiana University: Endurance Training and Alzheimer’s Disease Progression–Evidence and Mechanisms
  • Scott Phillips, University of Alabama at Birmingham: Muc5B Overexpression Increases Mitochondrial Dysfunction in Bleomycin-Induced Pulmonary Fibrosis

The University of Oklahoma Health Sciences Center

  • Dao-Fu Dai, University of Iowa Carver College of Medicine: Mitochondrial oxidative stress in kidney aging and chronic kidney diseases
  • Aditit Gurkar, University of Pittsburgh:Linking metabolism, DNA damage and longevity
  • Changwon Kho, Icahn School of Medicine at Mount Sinai: SUMOylatin as new molecular target for aging with muscular disease
  • Sreemathi Logan, University of Oklahoma Health Sciences Center: Assess the alterations in the metabolic state of astrocytes and assess its impact on cognitive function with age
  • Blanka Rogina, UCONN Health Center: Ameliorating the metabolic changes associated with Alzheimer's disease
  • Matthew Walters, University of Oklahoma Health Sciences Center: Aging-dependent changes in human airway stem/progenitor cell function
  • Hiroshi Yamada, University of Oklahoma Health Sciences Center: Using existing and frozen whole blood samples from 24m-old control wild type and Sgo1-/+, we will perform RNAseq analysis for whole transcriptome (messenger RNA-gene expression in the whole blood)

The University of Texas Health Science Center at San Antonio

  • Xianlin Han, The University of Texas Health Science Center at San Antonio: Sulfatide Deficiency: A Novel Driver of AD and Aging-Related Cognitive Impairment
  • Sang Eun Lee, The University of Texas Health Science Center at San Antonio: Mechanisms of Age-Related Chromosomal Instability
  • Teppei Fujikawa, The University of Texas Health Science Center at San Antonio: Mechanisms of Age-Related Chromosomal Instability
  • Allon Canaan, Yale University: Targeting the Adipocyte as a Key Site Whereby FAT10 Silencing Extends Lifespan and Healthspan
  • Constanza Cortes, Duke University: Skeletal Muscle TFEB signaling: a novel role in systemic aging and metabolism
  • Dena Dubal, University of California San Francisco: Role of Sex Chromosomes in Organismal Aging
  • William Ja, The Scripps Research Institute: Fluspirilene as a modulator of metabolism
  • Hongwei Si, Tennessee State University: Dietary epicatechin and aging-induced sarcopenia in mice
  • Michael Stout, University of Oklahoma: Sex Differences in the Response to Dietary Restriction: Relative Roles of Gonads and Sex Chromosomes
  • George Sutphin, University of Arizona: Development of a dietary pharmacological strategy to elevate systemic 3-hydroxyanthranilic acid

The University of Washington

  • Lauren Brent, University of Exeter: Metabolomic changes in naturally aging free-living rhesus macaques
  • Jason Chan, Juanita College: Role of sphingolipid signaling in host-bacterial interactions associated with aging
  • Joseph Rodgers, Keck School of Medicine: Dissecting the metabolic mechanisms that underlie age-associated defects in muscle stem cell function
  • George Sutphin, University of Arizona: Evaluating the impact of kynurenine pathway interventions on NAD biosynthesis
  • Dena Dubal, University of California San Francisco: Role of the Second X Chromosome in the Aging Female Brain: A Proteomic Approach
  • Richard Miller & Joe Endicott, University of Michigan: How CMA influences physiology, and the mechanisms of CMA upregulation in Snell dwarf mice
  • Yousin Suh, Albert Einstein College of Medicine: An integrated approach to elucidate the role of human longevity-associated LRP130 missense variants on mitochondrial function and cellular homeostasis
  • Jan Gruber, Yale-National University of Singapore: Prolong the lifespan of Caenorhabditis elegans to specifically identify synergistic pharmaceutical combinations in an unbiased and systematic manner
  • Alaattin Kaya, Brigham and Women's Hospital: Understanding of essential gene function in aging
  • Jeremy Van Raamsdonk, McGill University: Molecular mechanisms of lifespan extension: Role of kinase and phosphatase signaling

2017 Grantees

The Albert Einstein College of Medicine

  • Pinchas Cohen, University of Southern California
  • Dudley Lamming, University of Wisconsin-Madison
  • Daniel Promislow, University of Washington School of Medicine
  • Christian Sell, Drexel University College of Medicine
  • Yin Shen, University of California
  • Michael Stout, University of Oklahoma Health Sciences Center

The Jackson Laboratory

  • Muneer Hasham, The Jackson Laboratory: Determining the genetic variations that impact the age-related B-cell immune response
  • Duygu Ucar, The Jackson Laboratory: Epigenomic disruption of immune cell functions with aging in CC founder strains
  • Catherine Kaczorowski, The Jackson Laboratory: Systems Genetics of Normal Aging and Alzheimer's Disease
  • Ewelina Bolcun-Filas, The Jackson Laboratory: Genetics and Genomics of the Ovarian Reserve and Female Fertility
  • Olga Anczukow, The Jackson Laboratory: Identifying age-related changes in splicing regulation in the mammary gland
  • John Fryer, Mayo Clinic: Use single-cell RNAseq technology to determine the cellular response in all cell types in the aging brain

The University of Alabama at Birmingham

  • Peggy Biga, The University of Alabama at Birmingham: Long-term treatment with Teneurin C-terminal Associated Peptide (TCAP) improves metabolic efficiency and aging pathologies by regulating glucose metabolism and energy output
  • Liou Sun, The University of Alabama at Birmingham: Environmental temperature, GH signaling and energy metabolism of healthy aging
  • Karen Bernard, The University of Alabama at Birmingham: NADPH oxidase 4 control of metabolic reprogramming and its implication in apoptosis resistance of senescent lung fibroblasts
  • Thomas Buford, The University of Alabama at Birmingham: Role of the Gut Microbiome in Inflammation of Aging
  • Michael Sandel, The University of West Alabama: Toward a personalized bioenergetic health index: accounting for heredity and life history using structural mtDNA variants
  • Nicole Riddle, The University of Alabama at Birmingham: Altered metabolism in a chromatin mutant

The University of Oklahoma Health Sciences Center

  • Vineet D. Menachery, University of Texas Medical Branch: Establish age-dependent mouse model of SARS-CoV with the overall goal to identify host pathways to target for improved treatment of elderly populations.
  • Daniela C. Zarnescu, University of Arizona: Measure key redox readouts in ALS and aging flies. We propose to use the Redox Biology core to perform existing assays 1-3. These experiments will provide much needed information about the status of pathways we predict to be altered based on existing molecular and metobolomics profiling data we have in the ALS model.
  • Kristin E. Gribble, Marine Biological Laboratory:Quantify mitochondrial function and oxidative damage in mothers and offspring, to determine the effect of maternal age and maternal CR on mitochondrial homeostasis across generations.
  • Yuxian Sun, Texas A&M University: The bioinformatics tools will be used to analyze known aging markers and muscle anabolic/catabolic markers. We will use MEDLINE’s large-scale text mining software developed by Discovery Bioinformatics Core to search for linked proteins such as the ghrelin-associated regulatory pathway associated with aging, and describe the biological functions of the central protein by creating the network.
  • Je-Hyun Yoon, Medical University of Southern California:Post-analysis of total RNA sequencing and miRNA microarray data for differential RNA methylation and its correlation with steady-state level, differential miRNA expression and its correlation with target mRNA level and differential expression of target mRNAs interacting with age-associated RNA-binding proteins.
  • Timothy R. Peterson, Washington University St. Louis: Systematically assess the contribution of metabolites to redox and energy balance in human cells and to determine how metabolites regulate redox and energy balance in cancer and stem cells and in pairwise combinations.
  • John Tower, University of Southern California: Sequence mitochondrial DNA isolated from single, dissected oenocytes that are marked by Hsp22-GFP in middle-aged flies, as well as unmarked oenocytes from the same fly.
  • Marta Gonzales-Freire, University of Kentucky: Quantify mitochondrial DNA copy number and DNA mutational load in muscles from patients with Peripheral Artery Disease (PAD).
  • Ai-Ling Lin, University of Kentucky: Determine the effects of Rapa on metabolic changes associated with the heredity risk of APOE4. Also to determine redox status, mitochondrial integrity, and epigenetic changes within mTOR signaling and mitochondrial functions.
  • Deepa Sathyaseelan, University of Oklahoma Health Sciences Center: Develop a sensitive and quantitative assay to assess the necroptosis status of an animal (or human) by measuring the levels of mitochondrial DNA in blood.
  • Nicole R. Phillips, University of North Texas Health Sciences Center: Females exhibit age-related changes in mt DNA copy number over time which are due to altered epigenetic patterns of key mitochondrial biogenesis genes and is correlated with cognitive decline.
  • Yizhe Tang, Albert Einstein College of Medicine: DNA methylation analysis of innate immunity genes on the hypothalamus and htNSCs versus other brain regions/cell types in young, middle-aged and old mice using the loci-specific Bisulfite Amplicon Sequencing (BSAS). Genome-wide DNA methylation profiing of the hypothalamus and htNSCs in young, middle-aged, and old mice using Bisulfite Oligonucleotide Capture Sequencing (BOCS).
  • Jarrod Call, University of Georgia: To determine cellular role of Ulk1-mediated autophagy in mtDNA integrity and redox balance with age. To determine cellular role of Ulk1-mediated autophagy in mtDNA integrity and redox balance with injury.
  • Nathalie Sumien, University of North Texas Health Sciences Center: Determine how chronic glutathione deficiency affects redox status and energy balance across the lifespan of male and female mice.
  • Scott M. Plafker, Oklahoma Medical Research Foundation: Define the tissue- and cell-specific pathways that drive senescence in the retina.
  • Bumsoo Ahn, Oklahoma Medical Research Foundation:Development of in vivo oxidative stress markers
  • Siobhan Craige, University of Massachusetts: Muscle-specific NOX4 and oxidative stress.
  • Alessandro Bitto, University of Washington: Changes in acetylation status of mitochondrial enzymes in response to mitochondrial dysfunction.
  • Shailaja K. Allani, Florida Atlantic University: We aim to utilize the Discovery Bioinformatics novel software to analyze the transcriptome data and study gene regulation relevant to age-related diseases.

The University of Texas Health Science Center at San Antonio

  • Yidong Bai, The University of Texas Health Science Center at San Antonio: Mitigating ageing by shifting mitochondrial DNA heteroplasmy
  • Andrew Pickering, The University of Texas Health Science Center at San Antonio: Augmentation of proteasome function as an intervention to cognitive aging
  • Ramaswamy Sharma, The University of Texas Health Science Center at San Antonio: Targeting Caspase-2 for augmenting bone strength during aging
  • Ellen Kraig, The University of Texas Health Science Center at San Antonio: Rapamycin and acarbose in the elderly: Effects on inflammation and the microbiome
  • Paul Hasty, The University of Texas Health Science Center at San Antonio: Test acarbose as a suppressor of intestinal tumors
  • LuZhe Sun, The University of Texas Health Science Center at San Antonio: Investigation of age-associated genes that drive human breast cancer development and progression

The University of Washington

  • John Chaston, Brigham Young University: Microbiota-mediated methionine restriction in Drosophila melanogaster
  • Constanza Cortes, University of California San Diego: Enhanced Skeletal muscle proteostatsis as a determinant of CNS aging
  • Michael Garratt, University of Michigan Medical School: Proteomic analysis of slowed cardiac aging with acarbose and 17-a-estradiol
  • Laura Niedernhofer, The Scripps Research Institute: Identifying the causes of age-related increased ROS
  • Patrick Phillips & Jessica Preston, University of Oregon: A Systems level characterization of novel tissue specific regulators of aging plasicity
  • Karl Rodriguez, University of Texas Health Science Center at San Antonio: Celastrol as a potential therapeutic to longevity and healthspan
  • Birgit Schilling, Buck Institute for Research on Aging: New proteomics workflows measuring protein turnover in age-dependent muscle atrophy models
  • Je-Hyun Yoon, Medical University of South Carolina: RNA granules in mitochondrial function and lifespan regulation