The University of Southern California and Buck Institute for Research on Aging Nathan Shock Center
Oklahoma Nathan Shock Center
Specialized Core Areas
Administrative Core
- Provides effective leadership, administration, and management of the Center.
- Supports the External Advisory Board of distinguished scientists who provide review and recommendations to the executive leadership of the Center and engages in outreach activities, including workshops, courses, lectures and symbosia.
- Oversees and ensures dissemination of Center resources and research findings to the geroscience community and collaborates with other funded Nathan Shock Centers.
- Supports an inter-Nathan Shock Center Geropathology Research Resource (GRR) led by Dr. Warren Ladiges.
Research Development Core
- Provides support for researchers nation- and world-wide, most often junior faculty, to develop pilot data to aid in new project and career development. This is assisted by granting of competitive awards for pilot project support for studies in the basic biology of aging, using the key resources provided by our Resource Cores.
Core Leader
Jessica Young, PhD
EmailProtein Phenotypes of Aging Core
Services
- Support with design and execution of experiments using proteomics to ask aging–related questions
- Guidance and assistance in sample preparation for proteomics
- Targeted and discovery proteomics data collection
- Measurements of peptide abundance and half-life by mass spectrometry
- Software tools and support for the analysis of proteomics data. These include Skyline for targeted and SRM/PRM proteomics and Topograph for stable isotope half-life measurements. Workshops on software tools are held each year.
Metabolite Phenotypes of Aging Core
- Provides state-of-the-art hardware and software tools to detect, identify and quantify aging-associated metabolites.
- Assists in the experimental design and statistical analysis of these metabolite profiles.
- Develops novel analytical tools for more powerful analysis of metabolome studies.
Core Leader
Daniel Promislow, PhD
EmailInvertebrate Longevity and Healthspan Core
- Assists investigators throughout the research community in quantifying a variety of longevity and healthspan measures in two of the major invertebrate model organisms: the budding yeast Saccharomyces cerevisiae and the nematode Caenorhabditis elegans. This is accomplished through direct collaboration, training and outreach, and the development and dissemination of new tools and technologies. Visit the UW NSC website for the list of services available.
Artificial Intelligence and Bioinformatics Core
Services
- Statistical consultation on project design and data analysis (required for pilot projects)
- Statistical analysis of a variety of data types, often -omics and survival data from experiments performed by the other Cores
- Consultation on AI or computationally intensive projects in aging research
- Collaboration on application of AI methods to important problems in aging research
Core Leader
Su-In Lee, PhD
Email