Center Directors

David J. Marcinek, PhD

David J. Marcinek, PhD

Email
Jessica Young, PhD

Jessica Young, PhD

Email

Contact Details

Website |

1959 NE Pacific St., K-081 HSB
Seattle, WA 98195-7705

Administrative Core

  • Provides effective leadership, administration, and management of the Center.
  • Supports the External Advisory Board of distinguished scientists who provide review and recommendations to the executive leadership of the Center and engages in outreach activities, including workshops, courses, lectures and symbosia.
  • Oversees and ensures dissemination of Center resources and research findings to the geroscience community and collaborates with other funded Nathan Shock Centers.
  • Supports an inter-Nathan Shock Center Geropathology Research Resource (GRR) led by Dr. Warren Ladiges.

Core Leaders

David J. Marcinek, PhD

David J. Marcinek, PhD

Email
Jessica Young, PhD

Jessica Young, PhD

Email

Research Development Core

  • Provides support for researchers nation- and world-wide, most often junior faculty, to develop pilot data to aid in new project and career development. This is assisted by granting of competitive awards for pilot project support for studies in the basic biology of aging, using the key resources provided by our Resource Cores.

Core Leader

Jessica Young, PhD

Jessica Young, PhD

Email

Protein Phenotypes of Aging Core

Services

  • Support with design and execution of experiments using proteomics to ask aging–related questions
  • Guidance and assistance in sample preparation for proteomics
  • Targeted and discovery proteomics data collection
  • Measurements of peptide abundance and half-life by mass spectrometry
  • Software tools and support for the analysis of proteomics data. These include Skyline for targeted and SRM/PRM proteomics and Topograph for stable isotope half-life measurements. Workshops on software tools are held each year.

Core Leaders

Mike MacCoss, PhD

Mike MacCoss, PhD

Email
Judit Villen, PhD

Judit Villen, PhD

Email

Metabolite Phenotypes of Aging Core

  • Provides state-of-the-art hardware and software tools to detect, identify and quantify aging-associated metabolites.
  • Assists in the experimental design and statistical analysis of these metabolite profiles.
  • Develops novel analytical tools for more powerful analysis of metabolome studies.

Core Leader

Daniel Promislow, PhD

Daniel Promislow, PhD

Email

Invertebrate Longevity and Healthspan Core

  • Assists investigators throughout the research community in quantifying a variety of longevity and healthspan measures in two of the major invertebrate model organisms: the budding yeast Saccharomyces cerevisiae and the nematode Caenorhabditis elegans. This is accomplished through direct collaboration, training and outreach, and the development and dissemination of new tools and technologies. Visit the UW NSC website for the list of services available.

Core Leaders

Maitreya Dunham, PhD

Maitreya Dunham, PhD

Email
Alex Mendenhall, PhD

Alex Mendenhall, PhD

Email

Artificial Intelligence and Bioinformatics Core

Services

  • Statistical consultation on project design and data analysis (required for pilot projects)
  • Statistical analysis of a variety of data types, often -omics and survival data from experiments performed by the other Cores
  • Consultation on AI or computationally intensive projects in aging research
  • Collaboration on application of AI methods to important problems in aging research

Core Leader

Su-In Lee, PhD

Su-In Lee, PhD

Email