2018 Grantees

The Albert Einstein College of Medicine

  • Pinchas Cohen, University of Southern California:MOTS-C can act centrally to regulate insulin sensitivity
  • Fabien Delahaye, Albert Einstein College of Medicine: Single-cell on microglia
  • Jessica Mar and Ameya Kulkarni, Albert Einstein College of Medicine: Characterizing heterogeneity in Metformin action in aging mouse liver and adipose at a single-sell resolution using sc-RNA-SEQ
  • Jeff Mason, Utah State University: Ovarian transplantation with and without germ cells will produced unique DNA methylation fingerprints
  • Kevin Murach, University of Kentucky: Skeletal muscle epigenetics with aging
  • Thomas Perls, Boston University School of Medicine:Somatic mutations in the blood of centenarians using single cell sequencing
  • Senthil Radhakrishnan, Virginia Commonwealth University: Possible role for Nrf1 in the autophagy pathways - CIT
  • Michael Stout, University of Oklahoma Health Sciences Center: Unraveling the role of hypothalamic ERα activity in age-related declines in hepatic gluconeogenic plasticity
  • Qian Zhu, UC San Diego: C9ORF72 function affects the autophagy-lysosomal pathway in neurons

The Jackson Laboratory

  • Berenice Benayoun, University of Southern California: Sex dimorphism in aging macrophages
  • Danielle Bruns/Emily Schmitt, University of Wyoming: Linking Cardiac Aging with Biological Clock Activity
  • Aby Buchwalter, University of California San Francisco: Quantify nucleor size as a proxy for nucleolar activity over age in tissue sections at 6, 12 and 18 months
  • Melinda Duncan, University of Delaware: Consequences of Cataract Surgery in Aged Mice
  • Steven Gygi, Harvard University: The aged mouse proteome
  • Matt Kaeberlein, University of Washington: Examine and compare the effects of in-chow of 42mg/kg/day of rapamycin (42 ppm eRAPA) for 8 weeks (~2 months) on age-associated periodontal disease in wild-type C57BL/6 mice at 20 months of age.
  • Joseph McClay, Virginia Commonwealth University: Epigenetic Regulation of Drug Metabolizing Enzymes in Aging
  • Margarita Meer, Harvard University: Development of a blood-based DNA methylation clock in mice
  • Danitza Nebor, The Jackson Laboratory: Investigate whether decreasing of mTORC1 activity would increase the expression of the mouse bh1
  • Shohana Yakar, New York University: Test the effect of Methylene Blue on bone quality during Aging

The University of Alabama at Birmingham

  • Karthikeyani Chellappa, University of Pennsylvania: NAD metabolism and Aging: Impact on the composition of the gut microbiome
  • Helen E. Collins, University of Alabama at Birmingham: Dysregulation of local calcium signaling increases risk of diabetic cardiomyopathy in the aging female heart
  • Dao-Fu Dai, University of Iowa: Mitochondrial Oxidative Stress in Kidney Aging and Chronic Kidney Diseases
  • Amit Hagar, Indiana University: Endurance Training and Alzheimer’s Disease Progression–Evidence and Mechanisms
  • Scott Phillips, University of Alabama at Birmingham: Muc5B Overexpression Increases Mitochondrial Dysfunction in Bleomycin-Induced Pulmonary Fibrosis

The University of Oklahoma Health Sciences Center

  • Dao-Fu Dai, University of Iowa Carver College of Medicine: Mitochondrial oxidative stress in kidney aging and chronic kidney diseases
  • Aditit Gurkar, University of Pittsburgh:Linking metabolism, DNA damage and longevity
  • Changwon Kho, Icahn School of Medicine at Mount Sinai: SUMOylatin as new molecular target for aging with muscular disease
  • Sreemathi Logan, University of Oklahoma Health Sciences Center: Assess the alterations in the metabolic state of astrocytes and assess its impact on cognitive function with age
  • Blanka Rogina, UCONN Health Center: Ameliorating the metabolic changes associated with Alzheimer's disease
  • Matthew Walters, University of Oklahoma Health Sciences Center: Aging-dependent changes in human airway stem/progenitor cell function
  • Hiroshi Yamada, University of Oklahoma Health Sciences Center: Using existing and frozen whole blood samples from 24m-old control wild type and Sgo1-/+, we will perform RNAseq analysis for whole transcriptome (messenger RNA-gene expression in the whole blood)

The University of Texas Health Science Center at San Antonio

  • Xianlin Han, The University of Texas Health Science Center at San Antonio: Sulfatide Deficiency: A Novel Driver of AD and Aging-Related Cognitive Impairment
  • Sang Eun Lee, The University of Texas Health Science Center at San Antonio: Mechanisms of Age-Related Chromosomal Instability
  • Teppei Fujikawa, The University of Texas Health Science Center at San Antonio: Mechanisms of Age-Related Chromosomal Instability
  • Allon Canaan, Yale University: Targeting the Adipocyte as a Key Site Whereby FAT10 Silencing Extends Lifespan and Healthspan
  • Constanza Cortes, Duke University: Skeletal Muscle TFEB signaling: a novel role in systemic aging and metabolism
  • Dena Dubal, University of California San Francisco: Role of Sex Chromosomes in Organismal Aging
  • William Ja, The Scripps Research Institute: Fluspirilene as a modulator of metabolism
  • Hongwei Si, Tennessee State University: Dietary epicatechin and aging-induced sarcopenia in mice
  • Michael Stout, University of Oklahoma: Sex Differences in the Response to Dietary Restriction: Relative Roles of Gonads and Sex Chromosomes
  • George Sutphin, University of Arizona: Development of a dietary pharmacological strategy to elevate systemic 3-hydroxyanthranilic acid

The University of Washington

  • Lauren Brent, University of Exeter: Metabolomic changes in naturally aging free-living rhesus macaques
  • Jason Chan, Juanita College: Role of sphingolipid signaling in host-bacterial interactions associated with aging
  • Joseph Rodgers, Keck School of Medicine: Dissecting the metabolic mechanisms that underlie age-associated defects in muscle stem cell function
  • George Sutphin, University of Arizona: Evaluating the impact of kynurenine pathway interventions on NAD biosynthesis
  • Dena Dubal, University of California San Francisco: Role of the Second X Chromosome in the Aging Female Brain: A Proteomic Approach
  • Richard Miller & Joe Endicott, University of Michigan: How CMA influences physiology, and the mechanisms of CMA upregulation in Snell dwarf mice
  • Yousin Suh, Albert Einstein College of Medicine: An integrated approach to elucidate the role of human longevity-associated LRP130 missense variants on mitochondrial function and cellular homeostasis
  • Jan Gruber, Yale-National University of Singapore: Prolong the lifespan of Caenorhabditis elegans to specifically identify synergistic pharmaceutical combinations in an unbiased and systematic manner
  • Alaattin Kaya, Brigham and Women's Hospital: Understanding of essential gene function in aging
  • Jeremy Van Raamsdonk, McGill University: Molecular mechanisms of lifespan extension: Role of kinase and phosphatase signaling