2019 Grantees

The Albert Einstein College of Medicine

  • To Be Announced

The Jackson Laboratory

  • Katherine Aird, Penn State University: Investigating the Aging Microenvironment on Ovarian Cancer Biology
  • David Baglietto-Vargas, University of California, Irvine: Age-associated changes in the white adipose cells
  • Cintia De Paiva, Baylor University: Identifying Age-Related Changes in Molecular Signatures in Aged T Regulatory Cells
  • Melissa Duncan, University of Delaware: Validate RNA seq results comparing the response of aged and young mice to cataract surgery
  • Vivek Kumar, The Jackson Laboratory: Video analysis of gait in aged mice
  • Scott Leiser, University of Michigan: Determine the effect of mianserin supplementation at mid-life on aging
  • Chung-Ping Liao, UT Southwestern: The mechanism of aging-induced hair graying and hair loss in mammal
  • Rupa Sridharan, University of Wisconsin: Determining the epigenetic determinants of cellular aging
  • Chia Shan Wu, Texas A&M University: Effects of dietary soluble fiber supplementation on fecal microbiome and metabolome in aging mice

The University of Alabama at Birmingham

  • Melissa Harris, University of Alabama at Birmingham: Using melanocyte stem cells to address the role of quiescence in reduced stem cell function with age
  • Dudley William Lamming, University of Wisconsin-Madison: Regulation of central metabolism by calories and fasting
  • Merry-Lynn McDonald, University of Alabama at Birmingham: Mitochondrial Function, Sarcopenia and Chronic Obstructive Pulmonary Disease (COPD)
  • Orian Shirihai, David Geffen School of Medicine: Testing the methods for measuring mitochondrial function in frozen-thawed mononuclear cells and platelets
  • Quihong Li, University of Florida, and Patricia Jumbo-Lucioni, Samford University: Establishing the methodological basis for a high throughput screening of genetically modified probiotics in aging and Alzheimer’s disease models

The University of Oklahoma Health Sciences Center

  • Amandine Chaix, Salk Institute: Cardiac benefits of restricted feeding in aged mice
  • Karolina Chwalek, Harvard University: Model of epigenetically driven accelerated aging
  • Chathurika Henpita, University of Minnesota: Changes in metabolic and redox status with aging
  • Farah Lubin, University of Alabama at Birmingham: Epigenetic Regulation of Astrocytosis in Aging
  • Jeffrey Mason, Utah State University: Study of ovary-dependent extension of longevity
  • Vineet Menachery, UT Medicine Galveston: Epigenetic Changes in Age-Dependent Viral Pathogens
  • Monica Sanchez-Contreras and Mariya Sweetwyne, University of Washington: Identification of organ-specific burden of mitochondrial DNA mutations
  • Madhan Subramanian, Oklahoma State University: An integrated study of glial cell senescence
  • George Sutphin, University of Arizona: Kynurenine effects on oxidative status during aging
  • Maria Torregrosa, New York University: Inorganic polyphosphate protection against ROS

The University of Texas Health Science Center at San Antonio

Internal

  • Patricia Dahia, The University of Texas Health Science Center at San Antonio: Tmem127, a novel tissue specific regulator of insulin sensitivity and lipogenesis
  • Paul Hasty, The University of Texas Health Science Center at San Antonio: Test acarbose as a suppressor of ageing and colorectal cancer
  • Lyudmila Rachek, University of South Alabama: Protection against mtDNA damage by targeting the DNA repair enzyme hOGG1
  • Pei Wang, The University of Texas Health Science Center at San Antonio: Targeting adipocyte to develop anti-obesity and metabolic diseases drug
  • Jiangchao Zhao, University of Arkansas: Investigation of the roles that human gut microbiome plays in healthy aging

External

  • Jeffrey B. Mason, Utah State University: Presence or absence of germ cells in young ovaries influences age-related changes
  • Jesse Bruce Owens, University of Hawaii: Relation between FoxO3 and longevity using mouse models
  • Qiang Tong, Baylor College of Medicine: The Role of SIRT3 NAD+ Dependent Deacetylase in Healthspan and Lifespan Regulation
  • Heather L. Vellers, Texas Tech University: Role of Genetic Background on Age-Related Changes in Mitochondrial Genome Dynamics
  • James Patrick White, Duke University: Can prior exposure to youthful circulation improve outcomes in old mice
  • Matthew J. Youngman, Villanova University: Functional and Morphological Assessment of the Golgi Across Multiple Tissues During Aging

The University of Washington

  • Berenice Benayoun, University of Southern California: Characterization of sex-dimorphic mechanisms in inflamm-aging
  • Danielle Bruns, University of Wyoming: Heart Failure across the life-course: a proteomic approach to identify circulating juvenile factors to protect the aging heart
  • Dena Dubal, University of California, San Francisco: Longevity and brain resilience
  • David Garcia, University of Oregon: The impact of prions on Aging
  • Alice Kane, Harvard Medical School: Metabolomic & Proteomic investigation of biological mechanisms of frailty in mice
  • Douglas Mashek, University of Minnesota: To determine the effects of Brummer overexpression on the Drosophila lipidome and metabolome
  • Claudia Moreno, University of Washington: Test hypothesis that there is a differential expression of ion channels and ion channel related proteins in the SAN from young and old mice
  • Brandt Pence, University of Memphis: Metabolomics for the Effect of GDF-15 Monocyte Immunosenescence
  • Marien Solesio, Rutgers University: Test whether PolyP is a key molecule in maintaining the appropriate mitochondrial bioenergetics in aging
  • Darci Trader, Purdue University: Assessing the effects of proteasome activators on lifespan
  • Amy Walker, University of Massachusetts - Medical School: Metabolic Integration of Aging & Stress Responses
  • Brian Wasko, University of Houston - Clear Lake: Lifespan effects resulting from mutations in the Bridge Helix Region of RNA Polymerase II that impact Metal Homeostasis
  • Qun Sophia Zang, University of Texas Southwestern: Regulation of Cardiac Metabolic Pathways during Endotoxemia in Aged Mice