The Albert Einstein College of Medicine Nathan Shock Center

• Jinan Behnan, Albert Einstein College of Medicine: The Landscape of Aging in Glioblastoma Microenvironment
• David Fooksman, Albert Einstein College of Medicine: Aging Enhances Plasma Cell Competition
• Seiya Kitamura, Albert Einstein College of Medicine: Restoring proteostasis through small molecule-induced degradation of soluble epoxide hydrolase
• Angela Lombardi, Albert Einstein College of Medicine: Pinpointing ER-Phagy in Aging Beta-Cell
• Maria Maryanovich, Albert Einstein College of Medicine: Reactive oxygen species (ROS) as neural signal transducers in the aging HSC niche
• Michael Ross, Albert Einstein College of Medicine: The effects of antiretroviral therapy upon kidney cellular senescence
• Nicholas Sibinga, Albert Einstein College of Medicine: Atherosclerosis and aging of the vascular wall

The Jackson Laboratory Nathan Shock Center

Pilot Project Awardees 2021-2022

• Olga Anczukow, The Jackson Laboratory: Transcriptomic and cellular programs during aging and in breast cancer
• Liisa Kuhn, UCHC: Quantifying Senescence in Mouse Mandibles
• Morgan Levine, Yale School of Medicine: Developing a lipid nanoparticle delivery platform
• Michael Lustgarten, Tufts University: Impact of a high-soluble fiber diet on the gut-muscle axis in aged mice
• Sarah Mitchell, Zurich: The role of Hydrogen Sulfide donors in mitigating frailty and age-related decline in genetically diverse outbred mice
• George Sutphin, University of Arizona: Testing of 3HAA
• Xu Zhang, Mayo Clinic: Preclinical testing of a senolytic drug to counter skeletal muscle aging

San Diego Nathan Shock Center

• Nicole Coufal, University of California San Diego: Human microglial aging modeled through mitochondrial progeria mutations
• Dibyadeep Datta, Yale University: Elucidating the Spatial and Temporal Progression of Pathology of Alzheimer’s Disease at Single-Cell Resolution in Non-Human Primates
• Caroline Kumsta, Sanford Burnham Prebys Medical Discovery Institute: Heterogeneity of autophagy during aging
• Sarah Ocañas, Oklahoma Medical Research Foundation: The effect of estrogen signaling modulation on female-specific microglial heterogeneity in the mouse hippocampus
• Andrey Parkhitko, University of Pittsburgh: Defining downstream mechanisms of methionine restriction by using single-cell sequencing
• Lichao Wang, UConn Center on Aging: Proteomic mechanisms of lifespan and healthspan extension by targeting p21high cell in vivo
• Zhen Zhou, University of California San Diego: Combining single-cell transcriptomics with live-cell imaging to unravel divergent aging trajectories in yeast

The University of Alabama at Birmingham Nathan Shock Center

• Jarrod Barnes, University of Alabama at Birmingham: O-Linked N-Acetylglucosamine Regulates Aging Hallmarks in Pulmonary Arterial Hypertension
• Sara Casado Zapico, New Jersey Institute of Technology: Development of the first epigenetic clock in tooth tissues. Towards a better understanding of tooth aging
• Stefani Krick, University of Alabama at Birmingham: The Cystic Fibrosis Airways – establishing a novel in vitro and in vivo model to study the biology of aging in the lung
• Manuel Rosa-Garrido, University of Alabama at Birmingham: Role of chromatin structure in mediating the pathological effects of cardiac aging
  
• Keshav Singh, University of Alabama at Birmingham: Establishing mitochondrial dysfunction as a hallmark of ovarian aging
  
• Daniel Tyrrell, University of Alabama at Birmingham: Determining cytotoxic T cell phenotype and function in the aging brain
  

Oklahoma Nathan Shock Center

• Bumsoo Ahn, Wake Forest University: The role of aging in skeletal and cardiac muscle wasting and weakness in tumor bearing mice
• Sara Casado-Zapico, New Jersey Institute of Technology: Development of the first epigenetic clock in tooth tissues. Towards a better understanding of tooth aging
• Amandine Chaix, University of Utah: Mechanisms of time-restricted feeding and calorie restriction -mediated health benefits
• Carlos Diaz Garcia, University of Oklahoma Health Sciences: Proteomic adaptations to mitochondrial calcium uniporter deficiency in neurons
• Michael MacArthur, Lewis-Sigler Institute for Integrative Genomics: Assessing mitochondrial DNA integrity as a function of age and heredity in a captive colony of 105 Glossophaga soricina bats

USC-Buck Nathan Shock Center

Year 3 Awards

• Berenice Benayoun, University of Southern California: Characterizing phenotypic outcomes of transposon candidate regulatory variants
• Christine Charvet and Emily Graff, Auburn University: Building translational tools to bridge the gap between aged humans and cats
• Constanza Cortes, University of Southern California: Geroprotective Effects of Exercise-Associated Factors on Skeletal Muscle Aging
• Andrew Gordus, Johns Hopkins University: The development of a cell-type atlas for young and aged spiders through scRNA sequencing
  
• Cristal Hill, Pennington Biomedical Research Center at Louisiana State University: The impact of a low-protein diet on protein regulation in aging mice
• Derrick Morton, University Southern California: Transcriptomic Signatures of Age-Related Neurodegeneration in Drosophila
• Laura Musselman, Binghamton University: Genomic translation of Drosophila and human healthy aging genes
• Nicole Riddle, University of Alabama at Birmingham: The Polycomb system and activity levels during aging: Establishing a link in humans
• Alex Soukas, Massachusetts General Hospital: Genetic mechanisms of lifespan and healthspan extension by metformin and phenformin
  

San Antonio Nathan Shock Center

Internal

• Jun Zhang, Cardiolipin Remodeling by ALCAT1 Links Mitochondrial Dysfunction to Inflammaging
• Stephanie Perez, Examination of an AD related endophenotype associated with perimenopause
• Sarah Hopp, Investigating the role of microglial sialylation in aging and ADRD
• Egle Prewit, Klotho, longevity, and breast cancer progression in female mice offspring of obese mothers

External

• Micah Drummond, University of Utah: Lipidomic signature during the recovery period in muscle remodeling during re-ambulation after a disuse period
• Sarah Jayne Mitchell, Princeton University: Pathology: mouse lifespan study of methionine restriction, mild (15%) calorie restriction, and a weight loss drug
• Sailendra Nichenametla, Orentreich Foundation for the Advancement of Science: Sulfur amino acid restriction-induced, feed-fast cycle-associated changes in lipidome
• Andrey Parkhito, University of Pittsburgh School of Medicine: Targeting methionine or tyrosine metabolism starting late in life to extend healthspan
• Jessica Proulx & Peter Adams, Sanford Burnham Prebys Medical Discovery Institute: Investigating Lipidomic Changes in Liver Aging and Senescence
• John Tower, University of Southern California: Mifepristone regulation of lipid metabolism in Drosophila and Mouse
• Lei Zhang & Paul Robbins, University of Minnesota: Unraveling the Mechanisms of a Novel Lipid Senolytic Using Lipidomics

Naked mole-rat tissues supplied

• Mark Horowitz, Yale University School of Medicine

The University of Washington Nathan Shock Center

Year 3 Awards

• Suzanne Angeli, University of Maine: Determining how modulation of mitochondrial permeability transition pore (mPTP) impacts aging in C. elegans
• Christine Charvet, Auburn University: Align reads for ATAC and RNA sequencing so that we can align ages across species
• Samantha Lewis, University of California Berkeley: Targeting mitochondrial genome ploidy to rejuvenate cellular homeostasis
  
• Enoch Ng'oma, University of Missouri: The age-specific metabolic profile of long-term dietary selection in a diverse Drosophila population
  
• Mark Phillips, Oregon State University: Characterizing P-body formation across yeast lifespan
• Andrew Wojtovich, University of Rochester: mtON in yeast
  
• Brian Zid, University of California San Diego: Characterizing P-body formation across yeast lifespan