2020 Grantees

The Albert Einstein College of Medicine

  • Costanza Cortes, University of Alabama: Transcription Factor E-B (TFEB) as Master Transcription Factor Regulator of Proteostasis, Integrating Autophagy and Bioenergetics in Aging
  • Sofia de Oliveira, Albert Einstein College of Medicine: Understanding Neutrophil Function in Age-Related Immunometabolic Dysfunction
  • Richard Kitsis, Albert Einstein College of Medicine: Fundamental Senescence-Cell Death and Optimal Cell Death Programs for Senolysi
  • Sayan Nandi, Albert Einstein College of Medicine: Microglial Protein Iba1 in Age-Related Mood and Cognitive Decline and Neuronal Injury
  • Simone Sidoli, Albert Einstein College of Medicine: Identifying Markers of Accessible Heterochromatin in Centenarians to Understand Enhanced Healthspan
  • Stefano Tarantini, University of Oklahoma: Role of circulating IGF-1 in vascular endothelial function

The Jackson Laboratory

  • Erik Bloss, The Jackson Laboratory: Investigate the neuroanatomical targets for subsequent genetic or molecular manipulations aimed at arresting or reversing aging-related cognitive decline
  • Kataryzna Cieslik, Baylor College of Medicine: Examine the proteome changes in the young and aged cardiac fibroblasts
  • George Sutphin, University of Arizona: Evaluate the efficacy of 3HAA at extending healthy lifespan in mice.
  • Jennifer Trowbridge,The Jackson Laboratory: Aim 1: Test the hypothesis that there is a negative correlation between myeloid-biased hematopoiesis and estrogen levels in middle-aged female mice. Aim2: Test the hypothesis that restoring estrogen in middle-aged female mice rejuvenates lineage-balanced hematopoiesis
  • Christopher Wiley, Buck Institute for Research on Aging: In vivo assessment of a polyunsaturated fatty acid that kills senescent cells

The University of Alabama at Birmingham

  • Stanislava Chtarbanova, The University of Alabama: Bioenergetics of virus infection in aged Drosophila
  • Eric P. Plaisance, The University of Alabama at Birmingham: Role of an exogenous ketone ester on histone deacetylase (HDAC) expression and age-related skeletal muscle loss
  • Debasish Sinha, University of Pittsburgh School of Medicine: Linking metabolic changes to neutrophil activation in the pathogenesis of age-related macular degeneration (AMD)
  • Josh Stern, The University of Alabama at Birmingham: Gene Expression Changes from Telomere Shortening and the Impact on Oxidative Stress
  • Michael Stout, University of Oklahoma Health Sciences Center: Mechanisms of metabolic, inflammatory, and healthspan enhancement by 17alpha-estradiol

The University of Oklahoma Health Sciences Center

  • Tracy Anthony, Rutgers University: Dietary sulfur amino acid restriction and proteostasis control in mouse liver.

  • Danielle Bruns, University of Wyoming: Mechanisms of cardioprotection by metformin in the aging right heart.

  • John Collins, Thomas Jefferson University: Activating SIRT6 to attenuate age and OA-associated oxidative stress in human chondrocytes.

  • Nathan LeBrasseur, Mayo Clinic: Examining the transcriptional landscape of vital organs to determine how endocrine disruption impacts aging biology.

  • Chi Fung Lee, Oklahoma Medical Research Foundation: Interactions between mitochondrial dysfunction, oxidative stress and aging in regulating arrhythmogenesis and sudden cardiac death.

  • Richard Morimoto, Northwestern University; Anan Yu, Northwestern University; and Jian Li, Oklahoma Medical Research Foundation: Single cell transcriptome analysis to monitor cell stress resilience in the progression of cellular senescence.

  • Nicole Riddle, The University of Alabama at Birmingham: Developing mitochondrial damage and copy number assays for comparative aging studies.

  • Matthew Robinson, Oregon State University: Using kinetic proteomics to determine turnover of electron transfer flavoprotein in skeletal muscle mitochondria during obesity and aging.

The University of Texas Health Science Center at San Antonio

Internal

  • Jenna Bartley, University of Connecticut Health Center: The effect of metformin, rapamycin, and combination treatment on flu responses in aged mice
  • Milos Marinkovic, The University of Texas Health Science Center at San Antonio: Role of Matricellular CCN1Cyr61 protein as regulator of MSCs in bone maintenance
  • Naomi Sayre, The University of Texas Health Science Center at San Antonio: LRP1 mediated activation of neurotoxic astrocytes and the effect on brain aging
  • Christi Walter, The University of Texas Health Science Center at San Antonio: The APEX1 Interactome in Germ Cell Aging

External

  • Karthikeyani Chellappa, University of Pennsylvania: Causal role of the microbiome in age-related decline in musculoskeletal health
  • Zachary Clayton, University of Colorado Boulder: The marmoset as a model of large elastic artery stiffening with human aging
  • Joseph Endicott, University of Michigan: Evaluation of Small-Molecule p110 Inhibitors for Long-Term Administration to Mice as a Method of Chemical Modulation of Chaperone-Mediated Autophagy
  • Nady Golestaneh, Georgetown University School of Medicine: The role of telmisartan in age-related macular degeneration
  • Louis R. Lapierre, Brown University: Nuclear export inhibition as an emerging anti-aging intervention
  • Scott F. Leiser, University of Michigan: The role of the serotonin antagonist drug mianserin in mammalian aging
  • Michal Masternak, University Central Florida: The genetic signature of functional and behavioral differences between white adipose tissue’s cell populations in long-living mice
  • Anja Nohe, University of Delaware: Developing a mouse model for age related Osteoporosis reflecting aberrant BMP2 signaling observed in human patients
  • Brandon Roberts,University of Alabama at Birmingham: The effects of an Exogenous Ketone Diet on the Liver and Skeletal Muscle Lipidome
  • Don Zack, Johns Hopkins University School of Medicine: Analysis of Aging In the Marmorset Retina using Single Cell Transcriptomic Technology

University of Washington

No Pilot Awards issued in 2020.