2020 Grantees
The Albert Einstein College of Medicine
- Costanza Cortes, University of Alabama: Transcription Factor E-B (TFEB) as Master Transcription Factor Regulator of Proteostasis, Integrating Autophagy and Bioenergetics in Aging
- Sofia de Oliveira, Albert Einstein College of Medicine: Understanding Neutrophil Function in Age-Related Immunometabolic Dysfunction
- Richard Kitsis, Albert Einstein College of Medicine: Fundamental Senescence-Cell Death and Optimal Cell Death Programs for Senolysi
- Sayan Nandi, Albert Einstein College of Medicine: Microglial Protein Iba1 in Age-Related Mood and Cognitive Decline and Neuronal Injury
- Simone Sidoli, Albert Einstein College of Medicine: Identifying Markers of Accessible Heterochromatin in Centenarians to Understand Enhanced Healthspan
- Stefano Tarantini, University of Oklahoma: Role of circulating IGF-1 in vascular endothelial function
The Jackson Laboratory
- Erik Bloss, The Jackson Laboratory: Investigate the neuroanatomical targets for subsequent genetic or molecular manipulations aimed at arresting or reversing aging-related cognitive decline
- Kataryzna Cieslik, Baylor College of Medicine: Examine the proteome changes in the young and aged cardiac fibroblasts
- George Sutphin, University of Arizona: Evaluate the efficacy of 3HAA at extending healthy lifespan in mice.
- Jennifer Trowbridge,The Jackson Laboratory: Aim 1: Test the hypothesis that there is a negative correlation between myeloid-biased hematopoiesis and estrogen levels in middle-aged female mice. Aim2: Test the hypothesis that restoring estrogen in middle-aged female mice rejuvenates lineage-balanced hematopoiesis
- Christopher Wiley, Buck Institute for Research on Aging: In vivo assessment of a polyunsaturated fatty acid that kills senescent cells
The University of Alabama at Birmingham
- Stanislava Chtarbanova, The University of Alabama: Bioenergetics of virus infection in aged Drosophila
- Eric P. Plaisance, The University of Alabama at Birmingham: Role of an exogenous ketone ester on histone deacetylase (HDAC) expression and age-related skeletal muscle loss
- Debasish Sinha, University of Pittsburgh School of Medicine: Linking metabolic changes to neutrophil activation in the pathogenesis of age-related macular degeneration (AMD)
- Josh Stern, The University of Alabama at Birmingham: Gene Expression Changes from Telomere Shortening and the Impact on Oxidative Stress
- Michael Stout, University of Oklahoma Health Sciences Center: Mechanisms of metabolic, inflammatory, and healthspan enhancement by 17alpha-estradiol
The University of Oklahoma Health Sciences Center
Tracy Anthony, Rutgers University: Dietary sulfur amino acid restriction and proteostasis control in mouse liver.
Danielle Bruns, University of Wyoming: Mechanisms of cardioprotection by metformin in the aging right heart.
John Collins, Thomas Jefferson University: Activating SIRT6 to attenuate age and OA-associated oxidative stress in human chondrocytes.
Nathan LeBrasseur, Mayo Clinic: Examining the transcriptional landscape of vital organs to determine how endocrine disruption impacts aging biology.
Chi Fung Lee, Oklahoma Medical Research Foundation: Interactions between mitochondrial dysfunction, oxidative stress and aging in regulating arrhythmogenesis and sudden cardiac death.
Richard Morimoto, Northwestern University; Anan Yu, Northwestern University; and Jian Li, Oklahoma Medical Research Foundation: Single cell transcriptome analysis to monitor cell stress resilience in the progression of cellular senescence.
Nicole Riddle, The University of Alabama at Birmingham: Developing mitochondrial damage and copy number assays for comparative aging studies.
Matthew Robinson, Oregon State University: Using kinetic proteomics to determine turnover of electron transfer flavoprotein in skeletal muscle mitochondria during obesity and aging.
The University of Texas Health Science Center at San Antonio
Internal
- Jenna Bartley, University of Connecticut Health Center: The effect of metformin, rapamycin, and combination treatment on flu responses in aged mice
- Milos Marinkovic, The University of Texas Health Science Center at San Antonio: Role of Matricellular CCN1Cyr61 protein as regulator of MSCs in bone maintenance
- Naomi Sayre, The University of Texas Health Science Center at San Antonio: LRP1 mediated activation of neurotoxic astrocytes and the effect on brain aging
- Christi Walter, The University of Texas Health Science Center at San Antonio: The APEX1 Interactome in Germ Cell Aging
External
- Karthikeyani Chellappa, University of Pennsylvania: Causal role of the
microbiome in age-related decline in musculoskeletal health
- Zachary Clayton, University of Colorado Boulder: The marmoset as a
model of large elastic artery stiffening with human aging
- Joseph Endicott, University of Michigan: Evaluation of
Small-Molecule p110 Inhibitors for Long-Term Administration to Mice as a
Method of Chemical Modulation of Chaperone-Mediated Autophagy
- Nady Golestaneh, Georgetown University School of Medicine: The role of
telmisartan in age-related macular degeneration
- Louis R. Lapierre, Brown University: Nuclear export
inhibition as an emerging anti-aging intervention
- Scott F. Leiser, University of Michigan: The role of the
serotonin antagonist drug mianserin in mammalian aging
- Michal Masternak, University Central Florida: The genetic signature of functional and behavioral differences between white adipose tissue’s cell populations in long-living mice
- Anja Nohe, University of Delaware: Developing a mouse
model for age related Osteoporosis reflecting aberrant BMP2 signaling
observed in human patients
- Brandon Roberts,University of Alabama at Birmingham: The effects of an Exogenous Ketone Diet on the Liver and Skeletal Muscle Lipidome
- Don Zack, Johns Hopkins University School of Medicine: Analysis of Aging In the Marmorset Retina using Single Cell Transcriptomic Technology
University of Washington
No Pilot Awards issued in 2020.