2017 Grantees

The Albert Einstein College of Medicine

  • Pinchas Cohen, University of Southern California: MOTS-c can act centrally to regulate insulin sensitivity
  • Dudley Lamming, University of Wisconsin-Madison: Can youthful circulating factors delay the progression of cardiovascular disease in progeroid mice?
  • Daniel Promislow, University of Washington School of Medicine: Epigenetics and epigenetic memory in aging fruit fly
  • Michael Stout, University of Oklahoma Health Sciences Center: Evaluation of age and sex specific metabolic responses to short-term 17 a-estradiol infusions

The Jackson Laboratory

  • Muneer Hasham, The Jackson Laboratory: Determining the genetic variations that impact the age-related B-cell immune response
  • Duygu Ucar, The Jackson Laboratory: Epigenomic disruption of immune cell functions with aging in CC founder strains
  • Catherine Kaczorowski, The Jackson Laboratory: Systems Genetics of Normal Aging and Alzheimer's Disease
  • Ewelina Bolcun-Filas, The Jackson Laboratory: Genetics and Genomics of the Ovarian Reserve and Female Fertility
  • Olga Anczukow, The Jackson Laboratory: Identifying age-related changes in splicing regulation in the mammary gland
  • John Fryer, Mayo Clinic: Use single-cell RNAseq technology to determine the cellular response in all cell types in the aging brain

The University of Alabama at Birmingham

  • Peggy Biga, The University of Alabama at Birmingham: Long-term treatment with Teneurin C-terminal Associated Peptide (TCAP) improves metabolic efficiency and aging pathologies by regulating glucose metabolism and energy output
  • Liou Sun, The University of Alabama at Birmingham: Environmental temperature, GH signaling and energy metabolism of healthy aging
  • Karen Bernard, The University of Alabama at Birmingham: NADPH oxidase 4 control of metabolic reprogramming and its implication in apoptosis resistance of senescent lung fibroblasts
  • Thomas Buford, The University of Alabama at Birmingham: Role of the Gut Microbiome in Inflammation of Aging
  • Michael Sandel, The University of West Alabama: Toward a personalized bioenergetic health index: accounting for heredity and life history using structural mtDNA variants
  • Nicole Riddle, The University of Alabama at Birmingham: Altered metabolism in a chromatin mutant

The University of Oklahoma Health Sciences Center

  • Vineet D. Menachery, University of Texas Medical Branch: Establish age-dependent mouse model of SARS-CoV with the overall goal to identify host pathways to target for improved treatment of elderly populations.
  • Daniela C. Zarnescu, University of Arizona: Measure key redox readouts in ALS and aging flies. We propose to use the Redox Biology core to perform existing assays 1-3. These experiments will provide much needed information about the status of pathways we predict to be altered based on existing molecular and metobolomics profiling data we have in the ALS model.
  • Kristin E. Gribble, Marine Biological Laboratory:Quantify mitochondrial function and oxidative damage in mothers and offspring, to determine the effect of maternal age and maternal CR on mitochondrial homeostasis across generations.
  • Yuxian Sun, Texas A&M University: The bioinformatics tools will be used to analyze known aging markers and muscle anabolic/catabolic markers. We will use MEDLINE’s large-scale text mining software developed by Discovery Bioinformatics Core to search for linked proteins such as the ghrelin-associated regulatory pathway associated with aging, and describe the biological functions of the central protein by creating the network.
  • Je-Hyun Yoon, Medical University of Southern California:Post-analysis of total RNA sequencing and miRNA microarray data for differential RNA methylation and its correlation with steady-state level, differential miRNA expression and its correlation with target mRNA level and differential expression of target mRNAs interacting with age-associated RNA-binding proteins.
  • Timothy R. Peterson, Washington University St. Louis: Systematically assess the contribution of metabolites to redox and energy balance in human cells and to determine how metabolites regulate redox and energy balance in cancer and stem cells and in pairwise combinations.
  • John Tower, University of Southern California: Sequence mitochondrial DNA isolated from single, dissected oenocytes that are marked by Hsp22-GFP in middle-aged flies, as well as unmarked oenocytes from the same fly.
  • Marta Gonzales-Freire, University of Kentucky: Quantify mitochondrial DNA copy number and DNA mutational load in muscles from patients with Peripheral Artery Disease (PAD).
  • Ai-Ling Lin, University of Kentucky: Determine the effects of Rapa on metabolic changes associated with the heredity risk of APOE4. Also to determine redox status, mitochondrial integrity, and epigenetic changes within mTOR signaling and mitochondrial functions.
  • Deepa Sathyaseelan, University of Oklahoma Health Sciences Center: Develop a sensitive and quantitative assay to assess the necroptosis status of an animal (or human) by measuring the levels of mitochondrial DNA in blood.
  • Nicole R. Phillips, University of North Texas Health Sciences Center: Females exhibit age-related changes in mt DNA copy number over time which are due to altered epigenetic patterns of key mitochondrial biogenesis genes and is correlated with cognitive decline.
  • Yizhe Tang, Albert Einstein College of Medicine: DNA methylation analysis of innate immunity genes on the hypothalamus and htNSCs versus other brain regions/cell types in young, middle-aged and old mice using the loci-specific Bisulfite Amplicon Sequencing (BSAS). Genome-wide DNA methylation profiing of the hypothalamus and htNSCs in young, middle-aged, and old mice using Bisulfite Oligonucleotide Capture Sequencing (BOCS).
  • Jarrod Call, University of Georgia: To determine cellular role of Ulk1-mediated autophagy in mtDNA integrity and redox balance with age. To determine cellular role of Ulk1-mediated autophagy in mtDNA integrity and redox balance with injury.
  • Nathalie Sumien, University of North Texas Health Sciences Center: Determine how chronic glutathione deficiency affects redox status and energy balance across the lifespan of male and female mice.
  • Scott M. Plafker, Oklahoma Medical Research Foundation: Define the tissue- and cell-specific pathways that drive senescence in the retina.
  • Bumsoo Ahn, Oklahoma Medical Research Foundation:Development of in vivo oxidative stress markers
  • Siobhan Craige, University of Massachusetts: Muscle-specific NOX4 and oxidative stress.
  • Alessandro Bitto, University of Washington: Changes in acetylation status of mitochondrial enzymes in response to mitochondrial dysfunction.
  • Shailaja K. Allani, Florida Atlantic University: We aim to utilize the Discovery Bioinformatics novel software to analyze the transcriptome data and study gene regulation relevant to age-related diseases.

The University of Texas Health Science Center at San Antonio

  • Yidong Bai, The University of Texas Health Science Center at San Antonio: Mitigating ageing by shifting mitochondrial DNA heteroplasmy
  • Andrew Pickering, The University of Texas Health Science Center at San Antonio: Augmentation of proteasome function as an intervention to cognitive aging
  • Ramaswamy Sharma, The University of Texas Health Science Center at San Antonio: Targeting Caspase-2 for augmenting bone strength during aging
  • Ellen Kraig, The University of Texas Health Science Center at San Antonio: Rapamycin and acarbose in the elderly: Effects on inflammation and the microbiome
  • Paul Hasty, The University of Texas Health Science Center at San Antonio: Test acarbose as a suppressor of intestinal tumors
  • LuZhe Sun, The University of Texas Health Science Center at San Antonio: Investigation of age-associated genes that drive human breast cancer development and progression

The University of Washington

  • John Chaston, Brigham Young University: Microbiota-mediated methionine restriction in Drosophila melanogaster
  • Constanza Cortes, University of California San Diego: Enhanced Skeletal muscle proteostatsis as a determinant of CNS aging
  • Michael Garratt, University of Michigan Medical School: Proteomic analysis of slowed cardiac aging with acarbose and 17-a-estradiol
  • Laura Niedernhofer, The Scripps Research Institute: Identifying the causes of age-related increased ROS
  • Patrick Phillips & Jessica Preston, University of Oregon: A Systems level characterization of novel tissue specific regulators of aging plasicity
  • Karl Rodriguez, University of Texas Health Science Center at San Antonio: Celastrol as a potential therapeutic to longevity and healthspan
  • Birgit Schilling, Buck Institute for Research on Aging: New proteomics workflows measuring protein turnover in age-dependent muscle atrophy models
  • Je-Hyun Yoon, Medical University of South Carolina: RNA granules in mitochondrial function and lifespan regulation