The Albert Einstein College of Medicine Nathan Shock Center

• Laura Cheney, Albert Einstein College of Medicine: Crossroads of HIV in the Aging Brain and Autophagy
• Sofiya DeOliviera, Albert Einstein College of Medicine: Understanding Neutrophil Function in Age-Related Immunometabolic Dysfunction
• David Fooksman, Albert Einstein College of Medicine: Aging Enhances Plasma Cell Competition
• Hang Lin, University of Pittsburgh: Autophagy and the aging of chondrocyte
  
• Angela Lombardi, Albert Einstein College of Medicine: Pinpointing ER-Phagy in Aging Beta-Cell
• Wenjie Luo, Weil Cornell Medicine Feil Family Brain & Mind Research Institute: Impact of pathologic tau on microglial autophagic activity
  
• Harini Sampath, Rutgers University: Testing gene expression of delta-9 desaturases and associated alterations in lipidomic profiles in young vs. aged and parabiosed cardiac tissues
  
• Matthew Yousefzadeh, University of Minnesota: Role of cell-non autonomous factors on the epigenetic landscape and DNA damage
  

The Jackson Laboratory Nathan Shock Center

• Justin Crane, Northeastern University: Determining the efficacy of 4-PBA to reverse age-related muscle frailty
• Cindia De Paiva, Baylor College of Medicine: The Effect of Senescence on the Aged Lacrimal Gland and Heart
• Karyn Frick, University of Wisconsin-Milwaukee: Effects of age, sex, and estradiol treatment on memory and affective function
• Chiara Rolando, University of Milan: Investigate alterations in α-Synucleindistribution and α-Synuclein-tubulin interaction in different types of synaptic terminals during aging
• Jennifer Trowbridge, The Jackson Laboratory: Evaluating age-associated clonal hematopoiesis in bone marrow
• Amy Wagers, Harvard Medical School: Cisd2 gene transfer as a potential rejuvenation therapy in aged mice
• Ashley Webb, Brown University: Investigate how genetic diversity affects the decline in neurogenesis in healthy aging

San Diego Nathan Shock Center

Year 1 Awards

• Ana Chucair-Elliott, Oklahoma Medical Research Foundation: A novel inducible cell-specific mouse model for chromatin accessibility and transcriptomic studies of retina Müller glia in age-related macular degeneration
• Vanessa Delcroix, The Scripps Research Institute:A single-cell atlas of the aging lacrimal gland to understand the mechanisms underlying age-associated dry eye disease
  
• Maria Clara Guida, Sanford Burnham Prebys Medical Discovery Institute:Investigating the epigenetic drift of aging hearts using Drosophila
  
• Adam Konopka, University of Wisconsin-Madison: The Metabolic-Epigenomic Network of Metformin and Exercise
  
• Lara Labarta Bajo, Salk Institute: Astrocyte Plasticity in the Aging Brain
  
• Maria Mihaylova, The Ohio State University: Characterizing Age-Dependent Changes in the Mammalian Colon
  

Year 2 Awards

• Leena Bharath, Merrimack College: Human T Cell Inflammation in Aging
• Shefali Krishna, Salk Institute for Biological Studies: Characterization and Function of Mitochondrial Age Mosaicism and Heterogeneity
• Gargi Mahapatra, Wake Forest School of Medicine: Identifying Mediators of Bioenergetic Decline in Peripheral Cells of Older Adults Across a Spectrum of Cognitive Abilities
• Chiara Nicoletti, Sanford Burnham Prebys Medical Discovery Institute: Extracellular Vesicles as Soluble Mediators of Accelerated Aging Within the Heterogeneous Population of Muscle-Resident Cells in Duchenne Muscular Dystrophy
• Anastasia Shindyapina, Brigham and Women's Hospital, Harvard Medical School: Unraveling Heterogeneous Biological Aging of Mouse Immune Cells at Single-Cell Resolution
• Xu Zhang, Mayo Clinic: The Dynamics and Heterogeneity of Cell Fates During Cellular Senescence

The University of Alabama at Birmingham Nathan Shock Center

Year 6 Awards

• Eugene Becker, UAB Department of Medicine: Aging-Associated Lung Fibrosis: Epithelial Bioenergetics and Regeneration
• Abbi Hernandez, UAB Department of Medicine: Impact of Regional Microbiome Specificity on Age- and Alzheimer’s Disease-Related Metabolic Impairment
• Deepa Satyaseelan, University of Oklahoma Health Science Center: The Role of Necroptosis on the Levels of Circulating Cell-Free mtDNA in Aging

Year 7 Awards

• Mladen Jergovic, University of Arizona: The role of Interlukin-6 in metabolic health in aging
• Teresa Liu, University of Wisconsin: Mitochondrial dysfunction leads to dysregulation of the Krebs cycle in BPH/LUTS
• Anna Thalacker-Mercer & Martha Field, University of Alabama at Birmingham & Cornell University: Impact of B12 deficiency on skeletal muscle mitochondrial DNA and function in advanced age

Oklahoma Nathan Shock Center

• Suzanne Angeli, Buck Institute for Research on Aging: Determining how loss of complex V and the mitochondrial unfolded protein response impact aging
• Dipayan Chaudhuri, University of Utah: Reducing mitochondrial protein turnover is a novel compensatory mechanism for preserving function in aging cardiomyocytes
• Yong Cheng, Oklahoma State University: Genome-wide DNA methylation analysis in aging mouse lung macrophages during Mycobacterium tuberculosis infection
• Bradley Gordon, Florida State University: Identifying Proteomic Changes in the Limb Skeletal Muscle in Response to Aging-Induced Androgen Deprivation
• Mladen Jergovic, University of Arizona: The role of Interlukin-6 in muscle mitochondrial metabolism in aging
• Kailiang Jia, Florida Atlantic University: Identification of novel genes involved in C. elegans food signaling by RNA-seq
• Kevin Murach and Yuan Wen, University of Arkansas and University of Kentucky: The Role of Satellite Cells in Epigenetic Adaptations to Lifelong Exercise
  
• Gaston Ofman, The University of Oklahoma Health Sciences Center: Novel blood cell mitochondrial biomarker of accelerated cardiac aging in premature children: A cross sectional study
• Andrey Parkhitko, University of Pittsburgh
• Stefano Tarantini, The University of Oklahoma Health Sciences Center: Effects of time-restricted feeding (TRF) on ROS generation and mitochondrial respiration in aged mice
• Heather Vellers, The University of Oklahoma: Genetic Contribution to HET3 Aging Mice Variation in Exercise Capacity Trainability

USC-Buck Nathan Shock Center

Year 1 Awards

• Berenice Benayoun, University of Southern California: Characterizing the transposon-induced secretome in human fibroblasts
• Guillaume Chanfreau, University of California Los Angeles: Splicing factor PRPF8 and degenerative disease phenotypes
  
• Zachary Clayton, University of Colorado Bolder: Using chip cytometry-based digital spatial profiling to elucidate novel mechanisms underlyingaortic stiffening with aging
• Weiwei Dang, Baylor University: Genetic association with Alzheimer disease and neurological outcomes
• Jingjing Li, University of California San Francisco: Construct a deep convolutional neural network to computationally assign cell ages to replicative old yeast cells
• Gordon Lithgow, Buck Institute: Analysis of polymorphisms in candidate human kinases for association with longevity and chronic neurological diseases
• Darcie Moore, University of Wisconsin-Madison: Uncovering the role of intermediate filaments in stress and aging using C. elegans
• John Newman, Buck Institute: HMGCS2 in Human Metabolism and Health
• Alexander Soukas, Massachusetts General Hospital: Sgk3 associations with aging-related metabolic phenotypes
• Nicole Stuhr, University of Southern California: Mass spec profiling of bacterial diets fed to C. elegans
  
• Christian Turner, University of Southern California: Neuropeptide profiling of SKN-1gf mutants
  
• Manlio Vinceguerra, University of Southern California: Compound Screening in C. elegans for improved healthspan
  
• Osvaldo Villa, University of Southern California: Defining Aldh4a1 variants in muscle health of normal adult aging
  
• Dan Winer, Buck Institute: The effects of mechanical tension on cell senescence and its secretory phenotypes

Year 2 Awards

• Angela Brooks, University of California, Santa Cruz: Investigating mechanisms of oncogene-induced senescence suppression by a splicing factor mutation
• Constanza Cortes, University of Alabama at Birmingham: Digital Profiling of Exercise-Associated Plasticity in the Aging Hippocampus
  
• Brian Diekman, University of North Carolina: The effect of stiffness on the secretory profile of senescent primary human chondrocytes
• Akos Gerencser, Buck Institute: Mitochondrial regulation of pancreatic beta-cell function in aging and type 2 diabetes
• Ryo Higuchi-Sanabria, University of Southern California: Hiding in Plain sight: the ubiquitous actin as a target for aging
  
• Ronald Irwin and Christian Turner, University of Southern California: Examining human Wdr23 SNPs in healthy brain aging
• Nicole Riddle, University of Alabama at Birmingham: Single-nuclei transcriptional profiling of muscle in response to exercise in Drosophila
  
• Marissa Schafer, Mayo Clinic: GeoMX Digital Spatial Profiling for discovery of senescence-related mechanisms driving dysfunction in the aged mouse brain
• Stefano Tarantini, University of Oklahoma: Single-cell effects of time-restricted feeding in the neurovascular unit of aged mice
• Osvaldo Villa, University of Southern California: Examining age-related RNA editing responses
• Kelvin Yen, University of Southern California: Investigation of a Conserved, Age-Related Mitochondrial Derived Peptide
• Yufeng Zhang, University of Memphis: Characterize senescent cell secretome in selected long-lived birds and mammals
  

San Antonio Nathan Shock Center

Internal

• Georgianna Gould, The University of Texas Health Science Center at San Antonio: Hippocampal NET01 Expression in Alzheimer's Disease
• Vaida Glatt, The University of Texas Health Science Center at San Antonio: Targeting Senescent Cells to Enhance Bone Healing in Aged Mice
• Guanshi Zhang, The University of Texas Health Science Center at San Antonio: PLPP3 deficiency contributes to endothelial dysfunction in kidney aging
• Juan Pablo Palavicini, The University of Texas Health Science Center at San Antonio: Extending invertebrate lifespan by preventing accumulation of liptoxic ceramides

External

• Cintia de Paive, Baylor College of Medicine: Age-Related Dry Eye
• Natasha Jaiswal, University of Pennsylvania: Biology of skeletal muscle aging: Therapeutic potential of FGFBP-1 in preventing sarcopenia
• Miranda Orr, Wake Forest University: Dasatinb and Quercetin Peripheral and CNS absorbance and brain penetration
• Daniel Wayne Trott, University of Texas Arlington: Role of CD8 T cells in age-related liver and visceral adipose inflammation

Naked mole-rat tissues supplied

• Young Jang, Emory University

The University of Washington Nathan Shock Center

Year 1 Awards

• Christopher Burtner and Andrew Rhyne, Roger Williams University: Adapting the WormBot Technology for the Study of Life Span in Rotifers
• Su-Jeong Kim, The Leonard Davis School of Gerontology, University of Southern California: Investigate the functional and mechanistic differential effects of SHLP2 and K4R SHLP2 on cellular protection
• Sovannarith Korm, Josephine Bay Paul Center for Comparative Molecular Biology & Evolution, Marine Biological Laboratory: Intergenerational effect of maternal age on offspring metabolome
• Amanda Melin and James Higham, University of Calgary/New York University: Metabolic profiles of age-related ocular disease in a non-human primate model
• Sarah Mitchell, ETH Zürich: Investigation of the effect of late-life interventions on the metabolome in male and female mice
• Vijay Yadav, Columbia University: Investigation of the effect of taurine on life- and health-span parameters in yeast and worms

Year 2 Awards

• Jonathan An, University of Washington- School of Dentistry: Metabolic Profling of the Aging Oral Cavity
• Ann Chiao, Oklahoma Medical Research Foundation: Age-dependent phospho-proteomic changes in heart failure with preserved ejection fraction
• Jose Garcia, U.S. Dept of Veteran Affairs: The Role of The Ghrelin Receptor GHSR-1a in Sarcopenia
• Alaattin Kaya, Virginia Commonwealth University: Identifying conserved essential genes that promote longevity
• Freya Mowat, University of Wisconsin-Madison: A pilot study of the association between whole blood metabolomic signatures, age, and heavy metal burden in companion dogs
• Andrey Parkhitko, University of Pittsburgh School of Medicine: Understand how metabolism is reprogrammed during aging and whether targeting reprogrammed metabolic pathways could extend health and lifespan
• Gregory Thatcher, University of Arizona: Nicotinamide phosphoribosyltransferase (NAMPT) positive allosteric modulators (N-PAMs)
• Jeremy Whitson, Davidson College: Establishment of the Mammalian Lens as a Model System for the Longitudinal Study of Protein Aging via Mass Spectroscopy