The Albert Einstein College of Medicine Nathan Shock Center

• Jiahn Choi, Albert Einstein College of Medicine: Mechanisms That Link Aging with Cancer Risk
• Molly Fisher, Montefiore/Albert Einstein College of Medicine: Urine Extracellular Vesicle Profiling to Determine Biological Differences in Kidney Aging in HIV+/HIV-Persons

The Jackson Laboratory Nathan Shock Center

• Denis Mogilenko, Vanderbilt University School of Medicine: Understanding dendritic cells as a driver of immune dysfunction in aging
• Jason Vevea, St. Jude Children’s Research Hospital: Age and sex dependent molecular changes in the synapse

San Diego Nathan Shock Center

Year 4 Awards

• Luis Prieto, Mayo Clinic: Building a holistic framework to explore cancer in aging
• Laith Samarah, Princeton University: Spatial Assessment of Cellular Heterogeneity in Aging
• Ines Sturmlechner, Mayo Clinic: Profiling age-dependent T cell fate heterogeneity and dysfunction
• Sonia Vazquez-Sanchez, University of California, San Diego: The Accelerated Aging Effect: Unmasking Cellular Hallmarks in Huntington’s Disease
• Daniel Whittaker, University of California, San Diego: Contributions of circadian disruption to the heterogeneity of brain aging
• Shanshan Yin, Sanford Burnham Prebys Medical Discovery Institute: Investigating the transcriptional and epigenetic heterogeneity in mammary glands during healthy aging and tumorigenesis

The University of Alabama at Birmingham Nathan Shock Center

• Victoria Gibbs, Associate Professor, University of Alabama at Birmingham: Evaluating the freshwater crustacean, Daphnia pulex, as an alternative, short-lived animal model of healthspan and aging
• Melissa Harris, Associate Professor, University of Alabama at Birmingham: Investigating the potential of the small molecule RT175 in regulating mitochondrial function to impact aging
• Hongying Wang, Postdoctoral Fellow, Texas A&M University: Ghrelin receptor in microglia mediates the pathology of Alzheimer’s disease in an age-dependent manner

Oklahoma Nathan Shock Center

• Timothy Allerton, Pennington Biomedical Research Center: Skeletal Muscle Proteomic Alterations in Heart Failure with Preserved Ejection Fraction: Impact of Exercise Training
• Marisol Castillo-Castrejon, University of Oklahoma Health Sciences: Ablated B cell estrogen signaling contributes to menopause-associated weight gain
• Carlos Diaz Garcia, University of Oklahoma Health Sciences: Metabolic reprogramming and oxidative stress in the brain of mice with mitochondrial Ca2+ uniporter hemizygosity
• David Hughes, Oklahoma Medical Research Foundation: Identifying a novel role for UBR5 in protein turnover and aging skeletal muscle
• Jacob Kirkland, Oklahoma Medical Research Foundation: Dissecting age-specific epigenetic regulation of the developmental loss of CNS axon growth ability
• Edwin Miranda, University of Utah: Effects of Protein Carbonylation and N-Acetyl-Carnosine on Proteostasis Mechanisms with Age
• Robert Musci, Loyola Marymount University: Investigating the turnover dynamics of mtDNA with stable isotope deuterium oxide
• Jaspreet Osan, University of North Dakota: Application of multi-omics approach to understand the physiological resilience of long-living mice fed high fat
• Ryan Tomlinson, Thomas Jefferson University: Investigating the turnover dynamics of mtDNA with stable isotope deuterium oxide
• Matt Yousefzadeh, Columbia University: Investigation of transcriptional changes in immune cell populations of mice treated with rapamycin

USC-Buck Nathan Shock Center

Year 4 Awards

• John Calambokidis & Simon Melov, Cascadia Research Collective & Buck Institute: Cellular resilience in an organoid muscle of the largest mammal that has ever lived
• Silvana Duran Ortiz, Ohio University: Single cell resolution assessment of senescence and DNA damage response in long-lived mice with adult-onset growth hormonal receptor disruption
• Wilber Escorcia, Xavier University: The effect of lipid buildup on genome stability
• Paul Seidler, University of Southern California: Alzheimer's tau drug development aided by phenotypic readouts using C. elegans
  
• Jonathan Wanagat, University of California Los Angeles: Human translation of RNA integrity assays
• Jeremy Whitson, High Point University: Examination of posttranslational modification and senescence in the aged and NDUFS4-/- mouse lens

San Antonio Nathan Shock Center

• Mariyam Akter & Rozalyn Anderson, University of Wisconsin-Madison: Astrocyte-directed remodeling of neuronal lipid metabolism
  
• Silvana Duran-Ortiz & John Kopchick, University of Ohio: Determining the end-of-life pathology of long-lived mice with adult-onset growth hormone receptor disruption
• Valentina Garbarino, UT Health San Antonio: Effect of lactoferrin on age-related hippocampal transcript and protein outcomes
• Catherine Kaczorowski, University of Michigan: Miglitol effects on cognitive performance in aging mice
• Lu Wang, UT Health San Antonio: Investigating Age-Related H3K36 Methylation Changes in Naked Mole-Rats
• Shangang Zhao, UT Health San Antonio: Effects of leptin modulation in healthspan and lifespan

The University of Washington Nathan Shock Center

Year 4 Awards

• Scott Leiser, University of Michigan Medical School: Determining expression patterns of lifespan-altering flavin containing mono-oxygenase genes
• Nicolas Lehrbach, Fred Hutch Cancer Research Center: Deciphering the role of Nrfs in longevity
• Mark McCormick, University of New Mexico: (title unknown, invertebrate core)
• Sailendra (Nath) Nichenametla, Orentreich Foundation for the Advancement of Science: Sulfur amino acid restriction-induced changes in energy metabolism are associated with altered protein glutathionylation during feed-fast cycles
• Dan Pollard, Western Washington University: Simultaneous mapping of natural genetic variants acting on replicative lifespan and age- associated aberrant gene expression from Sir2-dependent and independent loci/7/2023
  
• Alexander Gimelbrant, Altius Institute: Generation of the C.elegans strains for age-related chromatin accessibility studies
• Suman (Sumie) Jayadev, Harborview's Memory and Brain Wellness Center: Elucidating Age-induced Microglia State Change in Human Brain
  
• Andrey Parkhitko, University of Pittsburgh: effect of liver-specific Methioninase expression on the levels of methionine intermediates in the liver, plasma, and other organs
• Brian Wasko, Western University: Compensatory Mechanisms to Maintain Cellular pH Homeostasis