Upstate New York Nathan Shock Center
Rochester, NY
Specialized Core Areas
Live Animal Resource Core
Services
- Provide advice on study design involving unconventional animal models for aging research.
- Provide access to live naked mole rats, Damaraland mole rats, and African spiny mice for use in biogerontological research.
- Develop projects with investigators interested in using these species relevant to biogerontological research.
- Provide investigators with custom-collected samples.
Core Leader
Andrei Seluanov, PhD
EmailUnconventional Invertebrate Models Core
Services
- Provide advice on the design of aging studies utilizing unconventional invertebrate models (eusocial wasps and ants).
- Generate genomic, proteomic, and metabolomic data sets from unconventional invertebrate aging models and make them available to researchers in the aging field.
- Provide investigators with tissue samples from aged invertebrate individuals when available.
- Develop cell lines from wasps and ants and once developed, provide to interested investigators.
Frozen Zoo Biobank Resource Core
Services
- Provide advice on the design of comparative biology of aging studies. Assist with the statistical analysis of comparative biology data, including correction for confounding variables such as body mass and phylogeny.
- Provide frozen tissues and primary fibroblasts from 50+ species of mammals with diverse lifespans.
- Generate proteome data sets from non-standard model organisms and make them available to researchers in the aging field.
Core Leader
Vera Gorbunova, PhD
EmailComparative Omics Core
Services
- Provide support in experimental design, sample preparation, and data interpretation, along with access to training workshops and symposia for proteomics studies tailored to aging research.
- Protein identification, quantitation, and post-translational modification profiling.
- Advanced methodologies focused on protein homeostasis, including assays for protein oxidation and turnover kinetics.
- Single-cell proteomics using state-of-the-art mass spectrometers (Orbitrap Astral and timsTOF Ultra), enabling high-sensitivity analysis of cellular heterogeneity in aging tissues.
- Provide support for multiomics integration for aging research. Exploration of the aging-related genome elements and their functions in regulating the proteome and metabolome. Support for pathway and network analysis using proteomics and metabolomics data in conjunction with other omics layers.
Research Development Core
Services
- Incentivize and facilitate innovative aging research projects by offering competitive pilot project awards.
- Promote training and mentoring in aging research across the training continuum including developing mentoring committees for postdoctoral fellows and junior faculty and overseeing undergraduate Summer Research Internships.
- Foster scientific exchange and collaboration by supporting short-term visits for training or experiments and travel to conferences.
Core Leader
Kerry O’Banion, MD, PhD
Email