The Jackson Laboratory Nathan Shock Center

• Rafiou Agoro, The Jackson Laboratory: With Aging, Which Kidney Cells Lose Klotho First, And Why Some Mice May Lose More Than Others
• Sangyong Choi, University of Connecticut: The Impacts of Zinc Supplementation and Deficiency in Aged Mice and Their Combination with Senolytics
• Isha Jain, Gladstone Institutes: Uncovering the Genetic Variation and Basis for Vitamin Deficiencies with Age
• Camila Sabatini, University at Buffalo: Targeting the Biology of Oral and Dental Aging with Geroprotective Compounds

The University of Alabama at Birmingham Nathan Shock Center

• Davis Englund, University of Alabama at Birmingham: Evaluating the mechanistic contribution of p21 to skeletal muscle aging
• Michael Sandel, Mississippi State University: Uncovering the Role of 6mA Methylation in Vertebrate Metabolism and Aging
• Zhangli Su, University of Alabama at Birmingham: tRNA regulation in aging and lifespan determination

San Antonio Nathan Shock Center

• Costanza Cortes, University of Southern California: Synergistic Regulation of Skeletal Muscle Lipid Metabolism by Exercise and TFEB Overexpression
• Joel Encarnación-Rosado, Salk Institute for Biological Studies: Defining the Spatial and Metabolic Landscape of the Aging Pancreas
• Adam Konopka, University of Wisconsin-Madison: Pharmacokinetics of Everolimus in whole human blood samples
• Christina Towers, Salk Institute for Biological Studies: Defining the Spatial and Metabolic Landscape of the Aging Pancreas

The University of Washington Nathan Shock Center

• Alessandro Bitto, University of Washington: Characterization of the mitochondrial acetylome in response to age-associated mitochondrial dysfunction and its rescue by rapamycin
• Xinxian Deng, University of Washington: Probing aging-related disruption of the structure and regulation of the X chromosome in female brain
• Claire Han, Ohio State University: AI-Driven CHEMOtoxicity Prediction in Older Adults with Colorectal Cancer (AID-CHEMO): The Roles of Biological Aging and Geospatial Variation
• Pengyao Jiang, Arizona State University: Uncovering age-related mutation signatures through yeast models
• Alexander Lasher, Unviersity of Alabama at Birmingham: Probing mechanisms for the hepatic glucagon receptor’s regulation of lifespan
• Anupam Patgiri, Emory University: Proteomics-Based Mechanistic Insights into MiTAC2, a Mitophagy-Inducing Small Molecule for Sarcopenia
• Liza Severs, Fred Hutch: Establishing tools to investigate glial heterogeneity in neural aging
• Abhilasha Singh, Massachusetts General Hospital/Harvard Medical School: ATF6-Driven Metabolic Reprogramming in Frailty-Associated Accelerated Cardiac Aging and HFpEF
• Charlotte Smith, UC Davis: Sex-Specific Proteomic Profiling of Atrial Aging: Determining Associations Between Protein Signatures and Electrophysiological Remodeling
• Huiliang Zhang, Temple University: The metabolic and proteomic profiles of mitochondrial proton gradient restoration in cardiomyocyte aging

Aging Gene Discovery (AGeD) Collaborative Pilot Projects

(Collaboratively supported by the University of Washington, Oklahoma, and Jackson Laboratory Nathan Shock Centers)

• Chellappa Karthikeyani, Brown University: Genome wide CRISPR-Cas9 screen to identify nicotinamide transporter(s) in a human cell line