The Jackson Laboratory Nathan Shock Center

• John Bachman, The Jackson Laboratory: Impact of Aging on Immune Checkpoint Inhibitor Comorbidities
• Beth Dumont, The Jackson Laboratory: Quantifying Natural Variation in Reproductive Aging Across UM-HET3 and Wild-Derived Outbred Mice
• Emily Moore, Northeastern University: Studying Aging of the Periosteum and Interrogating the Anti-aging Potential of Fisetin
• Thomas O'Loughlin, Icahn School of Medicine: Defining the Role of a Tissue-Specific mTORC1 Modifier in Lifespan Regulation
• Anupam Patgiri, Emory University & Jaime Schneider, Harvard Medical School: In Vivo Evaluation of MiTAC2 for Restoring Mitochondrial Function in Aging Muscle
• Phillip West, The Jackson Laboratory: Metabolic Reprogramming with GLP-1 Therapy to Reverse Immune Aging
• Lei Zhang, University of Georgia: Clearing Senescent Cells in Naturally Aged Mice Using Next-Generation Senolytics

The University of Alabama at Birmingham Nathan Shock Center

• Muralidharan Anbalagan, Tulane University School of Medicine: A Novel Role for Estrogen Receptor alpha Phosphorylation in Metabolic Regulation and Healthy Aging
• Laura van Rosmalen, Salk Institute: Ambient Temperature Cycling as a Regulator of Metabolic Rhythmicity, Healthspan and Aging: A Comparative Organismal Analysis
• Angad Yadav, University of Alabama at Birmingham: Catabolic crises induces catabolic memory, impairs skeletal muscle regenerative recovery with aging

Wisconsin Nathan Shock Center

Year 1

• Jaspreet Kaur Osan, University of North Dakota: Plasma Aging Signatures Shaped by a Low-Fat, Methionine-Restricted Diet: A Liquid Biopsy Approach

Year 2

• David Beebe, Anna Huttenlocher, & Igor Slukvin, University of Wisconsin–Madison: Immunometabolism of neutrophils across the lifespan
  
• Romeo Blanc & Eric Yen, University of Wisconsin–Madison: Aged Stem Cells at Both Ends of the Gut–Muscle Axis: Metabolic Remodeling by Aerobic Exercise
• Carol Everson & Cassandra McGill, Medical College of Wisconsin: Impact of chronic sleep deficiency on brain aging
• Zachary Fennel, University of Utah: Age-related alterations in immunometabolism in skeletal muscle health and recovery
• Andrea Galmozzi, University of Wisconsin–Madison: Dissecting the Role of Adipose Heme Biosynthesis in Age-Related Metabolic Dysfunction
• Akihiro Ikeda, University of Wisconsin–Madison: Lipid dysregulation–driven microglial activation as a mechanism of accelerated retinal aging in Tmem135 mutant mice
• Elebeoba May, University of Wisconsin–Madison: Intersecting Effects of Aging and Vitamin D3 on Immune Response to Mycobacterium Infection
• Jaspreet Kaur Osan, University of North Dakota: Plasma Aging Signatures Shaped by a Low-Fat, Methionine-Restricted Diet: A Liquid Biopsy Approach
• Xuan Pan, University of Wisconsin–Madison: YY1‑Directed 3D Genome Architecture as a Driver of Metabolic and Lineage Homeostasis in Aging HSCs
• Mariana Pehar, University of Wisconsin–Madison: Linking lipid signaling and metabolism in astrocytes to neuroinflammation during aging
• Timothy Rhoads, University of Wisconsin–Madison: Acetylation of the RNA helicase DDX39B as a metabolic switch during caloric restriction
• Devin Schweppe, University of Washington: Mapping lipidomics changes of anti-inflammatory adaptation to aging in the spleen
• Wei Xu & Jin Zhang, University of Wisconsin–Madison: Investigating the functions of CARM1 in aging-related breast cancer bone metastasis

Upstate NY Nathan Shock Center

• Shah Ali, Columbia University Medical Center/Upstate Nathan Shock: Role of polyploidy as a buffer against oxidative stress in the aging mammalian heart
• Tasnim Arroum, Wayne State University School of Medicine: Deciphering Mitochondrial Tyrosine Phosphorylation Signatures In Short- And Long-Lived Mammals
• Fathima Athar Lynch & Eileen Redmond, University of Rochester Medicine: Leveraging Spiny Mice to Reveal New Mechanisms of Vascular Disease
• John Hatle, University of North Florida: Exploring healthspan upon increasing leucine catabolism in grasshoppers with global proteomics
• David Vermijlen, Université Libre de Bruxelles (ULB): Immunosurveillance by an invariant γδ TCR in the cancer-resistant naked mole-rat
• Yang Xiao, University of Pennsylvania: Cross-species epigenomic profiling of hepatocyte chromatin dynamics in metabolic stress

Aging Gene Discovery (AGeD) Collaborative Pilot Projects

(Collaboratively supported by the University of Washington, Oklahoma, and Jackson Laboratory Nathan Shock Centers)

• Davis Englund, University of Alabama at Birmingham: Discovery of Age-Related Gene Networks ControllingSkeletal Muscle Regeneration