The National Institute on Aging (NIA) Interventions Testing Program (ITP) was established to test compounds purported to extend lifespan and/or delay the onset of disease and disability. The NIA ITP tests such compounds in genetically heterogeneous mice, first using lifespan to assess the efficacy of interventions. There are three sites that perform the testing, one at the University of Michigan, one at the University of Texas Health Sciences Center-San Antonio, and one at The Jackson Laboratory. The ITP is a collaborative effort between the three testing sites and the sponsors who recommend interventions for study. The sponsor’s role is to provide the rationale for investigating the intervention and to make recommendations on the study design, including the dose and timing of administration. The sponsor will have access to all data developed from the treated mice, will assist in analysis of the data, and will be a co-author on resulting publications.

The NIA ITP is soliciting proposals for compounds to enter the study in 2027. The deadline for receipt of proposals is February 27, 2026. Information on the ITP and the instructions for preparing a proposal are posted on the ITP website, here. Completed application forms should be emailed to jennifer.fox@nih.gov.