WEBINAR | Incorporating Genetic Diversity in Mouse Models and the Potential for Precision-Medicine for Alzheimer’s

Tuesday, August 6, 2019 | 2-3pm Eastern (11am-12pm Pacific)

Watch the webinar recording here.

Catherine Kaczorowski, PhD of the Nathan Shock Center at the Jackson Lab has recently found that incorporating genetic diversity into modeling Alzheimer’s disease in mice resulted in greater overlap with the genetic, molecular, and clinical features of this pervasive human disease. This is the first study to show that you can replicate many of the molecular features of Alzheimer’s disease by interrogating diverse mouse models. Dr. Kaczorowski’s study was conducted with support from the NIA-supported open-science research consortia, the Resilience AD program, as well as grants from the American Federation for Aging Research (AFAR) and the Bright Focus Foundation.

In this free webinar, Dr. Kaczorowski explained her study’s core findings and explore how the study points to a strategy for better use of mouse models for precision medicine research—both basic and translational—for Alzheimer’s disease.

The one-hour webinar discussed:

  • How does adding genetic diversity improve the predictive power of mouse model studies Alzheimer’s disease research?

  • How do mouse models with genetic mutations help to define high-risk and well as protective genes and disease mechanisms and to efficiently test new potential therapeutics and interventions?

  • How does the ability to model genetic diversity impact multiple aspects of Alzheimer’s disease risk and resilience in transgenic mice and how does this study’s reproducibility impact the research community?

  • How does adding genetic diversity improve the predictive power of mouse models of aging?

A Q&A, facilitated by Steven N. Austad, PhD—Co-Principal Investigator of the Nathan Shock Centers Coordinating Center and Director of the Nathan Shock Center at the University of Alabama Birmingham—followed Dr. Kaczorowski’s presentation.

Watch here.


About the Presenter

Catherine Kaczorowski, PhD

Associate Professor, Envin Family Chair in Alzheimer’s Research - The Jackson Laboratory, Bar Harbor, Maine;

Assistant Professor of Medicine - Sacker School of Graduate Biomedical Sciences, Tufts University

Dr. Kaczorowksi’s research focus is to identify early causative events that underlie cognitive deficits associated with ‘normal’ aging and Alzheimer’s disease. Using sophisticated computational and statistical methods to merge knowledge from our mouse experiments with human data as well as combining systems genetics with innovative high resolution and high throughput membrane proteomics, viral-based gene transduction approaches, behavioral assays and electrophysiology, the Kaczorowksi Lab seeks to identify and understand how genetic factors and misregulated membrane proteins in the hippocampus of aging and AD mouse models alter hippocampal neuron excitability, functional connectivity of hippocampal neural networks, and memory.


About the Moderator

Steven N. Austad, PhD

Co-Principal Investigator, Nathan Shock Centers Coordinating Center; Director, Nathan Shock Center at the University of Alabama Birmingham; Distinguished Professor and Department Chair,

Department of Biology at the University of Alabama Birmingham; Scientific Director, American Federation for Aging Research

Dr. Austad’s current research interests include figuring out why organisms age at different rates, particularly in especially long-lived organisms such as quahog clams and hydra. He is also interested in studying indicators of animal healthspan as well as the effects of rapamycin on mouse healthspan. He is author of more than 190 scientific articles and more than 100 newspaper columns on science. His book, Why We Age: What Science Is Discovering About the Body’s Journey Through Life, has been translated into eight languages. Follow him on Twitter @StevenAustad.